Arteta is isolating and his assistant Albert Stuivenberg will take charge of the team as Arsenal attempt to stop the City juggernaut.
Arsenal have shot up the table in recent weeks and sit fourth after four wins in a row in the Premier League
But the visit of City will be a real test of their progress.
Pep Guardiola’s side have won 10 straight games in the Premier League, have opened up an eight-point lead at the top and look like they could run away with the title.
Date, kick-off time and venue
Arsenal vs Manchester City is scheduled for a 12:30pm GMT kick-off on Saturday, January 1, 2022.
The match will be played Emirates Stadium.
Where to watch Arsenal vs Man City
TV channel: The game will be broadcast on BT Sport 1 and BT Sport Ultimate.
Live stream: BT Sport subscribers will be able to watch the game through either their website or the BT Sport App..
Highlights will be available to watch from 10:45pm on BBC One.
Arsenal vs Man City team news
Calum Chambers and Maitland-Niles have returned to training to ease Arsenal’s right-back crisis.
Arsenal were without all four of their right-back options for their win at Norwich as Maitland-Niles, Chambers, Cedric and Takehiro Tomiyasu all tested positive for Covid-19.
Ben White had to fill in at right-back, but Chambers and Maitland-Niles are back in training and could return.
As of Friday, the Gunners had reported no fresh Covid cases, which means they could field the same team who beat Norwich 5-0.
For City, Joao Cancelo has travelled to London and is available after a violent assault on the Portuguese at his family home left him with facial injuries.
Cancelo suffered cuts to the face after attempting to fight off a gang of robbers at his family home on Thursday. But he wishes to be considered for selection despite the incident.
Kyle Walker has returned to training after injury so should Guardiola choose to rest Cancelo, who can operate as either full-back, City could play the England international at right-back, with Oleksandr Zinchenko and Nathan Ake options at left-back.
Riyad Mahrez is available for what is likely to be the last time before he goes off to the Africa Cup of Nations.
Rodri and John Stones are back in training after fitness issues and should be available..
Arsenal vs Man City prediction
Arsenal are undoubtedly in much better shape than when they were thrashed 5-0 at the Etihad in September, and their young guns should give City a proper test.
If the Gunners can produce another solid defensive display then they just might avoid a 10th straight Premier League defeat against City.
But City look almost unstoppable at the moment should have too much.